A Rare Case of Hepatic T-Cell Rich B-Cell Lymphoma (TCRBCL) in a JuvenileDog

Journal of Veterinary Medical Science

Catherine LAMM⁴  Jung-Woo LEE²  Dohyeon YU⁵  Ul-Soo CHOI¹  Tae-Ho CHUNG³  Young-Chul CHOI² 

[1] Department of Veterinary Clinical Pathology, Chonbuk National University, Jeonju-si, Jeollabuk-do 561�?756, South Korea;Africa Animal Medical Center, Gangseo-gu, Seoul 678�?709, South Korea;Department of Animal Science, Joongbu University, Gumsan-gun, Chungnam 312�?702, South Korea;IDEXX Laboratories, 2825 KOVR Drive, West Sacramento, CA 95605, U.S.A.;Department of Veterinary Clinical Pathology, Chonnam National University, Gwangju 500�?757, South Korea

关键词: diffuse large B-cell lymphoma;    hepatopathy;    juvenile dog;    lymphoma;    T-cell rich B-cell lymphoma;   

DOI  :  10.1292/jvms.14-0088

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(13)Cited-By(1)A 7-month-old castrated maleFrench Bull dog was presented with vomiting, lethargy, anorexia and weight loss of 2 weeksduration. The patient’s history and clinical manifestations of suspected hepatopathy weresubjected to ultrasonography, radiography, biochemical investigations and cytology ofhepatic lesion. The cytologic impression was hepatic lymphoma, which was later confirmedby histopathology. The neoplastic cells were strongly diffusely immunoreactive for PAX5,but not immunoreactive for CD3, and B lymphocyte specific clonal proliferation wasdetected using by assay of antigen receptor rearrangement. Large numbers of immunoreactivemature non-neoplastic lymphocytes were admixed with the neoplastic cell population.Therefore, the immunohistochemical results were definitively consistent with a T-cell richB-cell lymphoma (TCRBCL). This is the first description of a hepatic TCRBCL in a juveniledog showing a poor response to aggressive chemotherapy.

【 授权许可】

Unknown