BCGiosis as a presenting feature of a child with chronic granulomatous disease

Brazilian Journal of Infectious Diseases

Rezaei, Nima¹  Mamishi, Setareh²  Norouzi, Sayna²  Movahedi, Zahra² 

[1] Molecular Immunology Research Center;Tehran University of Medical Sciences, Tehran, Iran

关键词: BCG vaccine;    Mycobacterium bovis;    granulomatous disease;    chronic.;   

DOI  :  10.1590/S1413-86702011000100016

来源: Contexto

【 摘 要 】

Bacillus Calmette Guerin (BCG) vaccine, which is administered to all newborns in some regions, could lead to serious complication ranging from local disease (known as BCGitis) to disseminated disease (BCGosis) in a group of patients with primary immunodeficiency diseases. We are reporting here a 3.5 year-old girl with a history of prolonged BCGitis, which developed to disseminated disease without any other special features. Immunological studies with nitro-blue tetrazolium test confirmed the diagnosis of chronic granulomatous disease in this patient. Chronic granulomatous disease should be considered in the list of differential diagnosis in all children with BCGosis, even in the absence of any other manifestations related to immunodeficiency.

【 授权许可】

CC BY-NC-ND