Association of the ADIPOQ T45G polymorphism with insulin resistance and blood glucose: A meta-analysis

Endocrine Journal

Zhuo Liu²  Dingding Cao¹  Jianxin Wu¹  Shengrong Ouyang²  Feifei Ma² 

[1] Department of Biochemistry, Peking University Capital Institute of Pediatrics Teaching Hospital, Beijing 100020, China;Department of Biochemistry, Capital Institute of Pediatrics, Beijing 100020, China

关键词: Adiponectin;    Insulin sensitivity;    Single nucleotide polymorphisms (SNPs);    Meta-analysis;   

DOI  :  10.1507/endocrj.EJ13-0444

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(62)Cited-By(3)Results of published studies on the association of the ADIPOQ T45G polymorphism with insulin resistance (IR) and blood glucose are conflicting.In this study, we performed a meta-analysis to further investigate such an association.Articles that evaluate the effect of the T45G polymorphism on IR and blood glucose were identified from the PubMed and Embase databases.Five indices, including fasting blood glucose (FBG), fasting insulin (F-insulin), 2-h blood glucose (2-h BG), 2-h insulin, and homeostasis model assessment insulin resistance index (HOMA-IR), were used to assess the effects of the T45G polymorphism on IR and blood glucose under a dominant model.24 articles involving 7630 subjects were included.Twenty-two studies on FBG, 17 on F-insulin, 20 on HOMA-IR, and 3 on 2-h BG were included.No study on 2-h insulin was found.This meta-analysis revealed no significant association between the ADIPOQ T45G polymorphism and IR and blood glucose in the overall population and subgroup subjects under a dominant model, regardless of whether FBG, F-insulin, 2-h BG, or HOMA-IR was used.The present meta-analysis indicated that the mutation allele may have no function in IR development.The ADIPOQ T45G polymorphism is not associated with IR and blood glucose.

【 授权许可】

Unknown