Isotretinoin, depression and suicide: a review of the evidence

British Journal of General Practice

Parker Magin¹  Dimity Pond¹  Wayne Smith¹ 

[1] Discipline of general practice, University of Newcastle, New South Wales, Australia

关键词: acne vulgaris;    depression;    isotretinoin;    suicide;   

DOI  :  

学科分类：卫生学

来源: Royal College of General Practitioners

【 摘 要 】

There is currently considerable controversy regarding a proposed causal relationship between the use of isotretinoin and depression and suicide. A search was made of the MEDLINE, EMBASE and PsychINFO databases using the search terms ‘isotretinoin’, ‘depression’ and ‘suicide’. Despite numerous case reports linking isotretinoin to depression, suicidal ideation and suicide, there is, as yet, no clear proof of an association. While isotretinoin, used to treat acne vulgaris, has not been demonstrated to be associated with depression or suicide, the possibility of a relatively rare idiosyncratic adverse effect remains. GPs have a role in the clinical application of these findings.

【 授权许可】

Unknown