Altered MicroRNA Expression in the Ischemic–Reperfusion Spinal Cord With Atorvastatin Therapy

Journal of Pharmacological Sciences

Jia-Rui Hu²  Bang-Liang Yin¹  Guo-Hua Lv² 

[1] Department of Cardiothoracic Surgery, the Second Xiangya Hospital of Central South University, China;Department of Spine Surgery, the Second Xiangya Hospital of Central South University, China

关键词: ischemia–reperfusion injury;    atorvastatin;    microRNA;   

DOI  :  10.1254/jphs.12235SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(9)We explored the neuroprotection by atorvastatin in the ischemia/reperfusion model of rat and its microRNA-related mechanisms. At first, we uncovered a previously unknown alteration in temporal expression of a large set of microRNAs following spinal cord ischemia–reperfusion injury (IRI). The target genes for the differentially expressed microRNAs include genes encoding components that are involved in the inflammation, apoptosis, and neural damage that are known to play important roles in IRI. Atorvastatin pretreatment restored part of the up or down regulations. These findings suggest that altered expression of microRNAs may contribute to the mechanism of neuroprotection of statins in spinal cord IRI.

【 授权许可】

Unknown