期刊论文详细信息
Proceedings of the Nutrition Society | |
Insights into the role of macrophage migration inhibitory factor in obesity and insulin resistance | |
Fiona C. McGillicuddy1  Orla M. Finucane1  Clare M. Reynolds1  Helen M. Roche1  | |
关键词: Obesity; Inflammation; Insulin resistance; Adipose tissue macrophages; Macrophage migration inhibitory factor; | |
DOI : 10.1017/S0029665112000730 | |
学科分类:卫生学 | |
来源: Cambridge University Press | |
【 摘 要 】
High-fat diet (HFD)-induced obesity has emerged as a state of chronic low-grade inflammation characterised by a progressive infiltration of immune cells, particularly macrophages, into obese adipose tissue. Adipose tissue macrophages (ATM) present immense plasticity. In early obesity, M2 anti-inflammatory macrophages acquire an M1 pro-inflammatory phenotype. Pro-inflammatory cytokines including TNF-α, IL-6 and IL-1β produced by M1 ATM exacerbate local inflammation promoting insulin resistance (IR), which consequently, can lead to type-2 diabetes mellitus (T2DM). However, the triggers responsible for ATM recruitment and activation are not fully understood. Adipose tissue-derived chemokines are significant players in driving ATM recruitment during obesity. Macrophage migration inhibitory factor (MIF), a chemokine-like inflammatory regulator, is enhanced during obesity and is directly associated with the degree of peripheral IR. This review focuses on the functional role of macrophages in obesity-induced IR and highlights the importance of the unique inflammatory cytokine MIF in propagating obesity-induced inflammation and IR. Given MIF chemotactic properties, MIF may be a primary candidate promoting ATM recruitment during obesity. Manipulating MIF inflammatory activities in obesity, using pharmacological agents or functional foods, may be therapeutically beneficial for the treatment and prevention of obesity-related metabolic diseases.【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201911300419057ZK.pdf | 350KB | download |