The New Salicylate Derivative UR-1505 Modulates the Th2/Humoral Response in a Dextran Sodium Sulphate Model of Colitis That Resembles Ulcerative Colitis

Journal of Pharmacological Sciences

Mònica Comalada²  Antonio Zarzuelo²  Dolors Balsa¹  Isabel Ramis¹  Julio Gálvez²  Manuel Merlos¹  Pedro Michelena¹  Juan Román¹  Elvira Bailón² 

[1] Pharmacology & Toxicology, Palau Pharma S.A, Spain;Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), Department of Pharmacology, School of Pharmacy, University of Granada, Spain

关键词: inflammatory bowel disease;    B lymphocyte;    Th2-cytokine;   

DOI  :  10.1254/jphs.08292SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(4)The aim of the present study was to evaluate the inmunomodulatory effects of UR-1505, a new salicylate derivative, on the T helper (Th)2 / humoral response produced during dextran sodium sulfate (DSS)-induced rat colitis. In the in vitro studies, UR-1505 (300 μM) inhibited both the production of interleukin (IL)-10 and IL-5 in concanavalin A (Con A)-activated splenocytes and the production of immunoglobulin (Ig) G and IgA by B-lymphocytes. However, in contrast to the in vitro results, the administration of UR-1505 (10 and 30 mg/kg per day) to rats with established DSS-colitis enhanced both IL-10 and IgA production, whereas it inhibited IgG production, thus ameliorating the intestinal inflammation.

【 授权许可】

Unknown