Comparative Evaluation of Calcium-Sensitizing Agents, Pimobendan and SCH00013, on the Myocardial Function of Canine Pacing–Induced Model of Heart Failure

Journal of Pharmacological Sciences

Rieko Yoshiyuki¹  Keisuke Kawamura¹  Ryuji Fukushima¹  Ryo Tanaka¹  Toshiharu Fukayama¹  Soo-min Kim¹  Miki Shimizu²  Lina Hamabe¹ 

[1] Department of Veterinary Surgery, Tokyo University of Agriculture and Technology, Japan;Veterinary Diagnostic Imaging, Faculty of Veterinary Medicine, Tokyo University of Agriculture and Technology, Japan

关键词: animal model;    calcium sensitizer;    echocardiography;    heart failure;    inotropic agent;   

DOI  :  10.1254/jphs.13196FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(27)Cited-By(1)Pimobendan and SCH00013 are calcium sensitizers that possess dual action of calcium sensitization and phosphodiesterase-III inhibition. This study was conducted to comparatively evaluate the effect of these medications on the myocardial function of the canine pacing-induced heart failure model using echocardiography. Heart failure was induced in 20 dogs, to which pimobendan and two different doses of SCH00013 were administered orally to 15 dogs for 3 weeks, and the remaining 5 dogs served as the control. Cardiac evaluations were performed at baseline, week 1, week 2, and week 3. Significant thinning and dilation of the left ventricles, with systolic dysfunction, indicated by reduction of fractional shortening (FS) and strain values, were observed with a low dose of SCH00013. Whereas, although systolic dysfunction was observed with reduction of FS and radial strain, significant dilation and thinning of the left ventricles and reduction of circumferential strain were not observed with pimobendan. Pimobendan had a potent positive inotropic effect, with little effect on synchronicity, while low-dose SCH00013 had a weaker positive inotropic effect but was able to sustain synchronicity. Although, it failed to show significant statistical differences, the results of this study allow speculations that administration of pimobendan and SCH00013 may have differing effect on the myocardial function in the canine pacinginduced heart failure model.

【 授权许可】

Unknown