Canine IgA nephropathy: a case report

Journal of Veterinary Medical Science

Takako SHIMOKAWA MIYAMA¹  Moeko KOHYAMA²  Akira YABUKI²  Osamu YAMATO² 

[1] Laboratory of Veterinary Internal Medicine, Joint Faculty of Veterinary Medicine, Yamaguchi University, 1677�?1 Yoshida, Yamaguchi 753�?8515, Japan;Laboratory of Veterinary Clinical Pathology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1�?21�?24 Korimoto, Kagoshima 890�?8580, Japan

关键词: angiotensin-converting enzyme inhibitor;    canine;    IgA nephropathy;    proteinuria;    renal biopsy;   

DOI  :  10.1292/jvms.15-0161

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(11)Immunoglobulin (Ig) A nephropathy is a rare form of canine glomerular disease. Thisreport describes a case of canine IgA nephropathy showing characteristics typical of humanIgA nephropathy. An 8-year-old, spayed female Miniature Dachshund showed persistent severeproteinuria without azotemia. She was receiving long-term glucocorticoid therapy due tochronic gastritis and an intra-abdominal suture granuloma. A renal biopsy demonstratedmesangial proliferative glomerulonephritis with predominantly mesangial IgA deposition andelectron-dense deposits in the paramesangium. These findings closely resembled those ofhuman IgA nephropathy. Glucocorticoid treatment was discontinued, and theangiotensin-converting enzyme inhibitor enalapril was administrated as an antiproteinuricagent. The proteinuria subsequently went into remission, and the patient has maintainedgood condition without recurrence.

【 授权许可】

Unknown