Short term effects of levothyroxine treatment in thyroid multinodular disease

Endocrine Journal

Roberto Cesareo²  Enrico Di Stasio¹  Francesca Annunziata¹  Maria Antonietta Isgrò¹  Mario Iozzino³ 

[1] Institute of Biochemistry and Clinical Biochemistry, Catholic University of Sacred Heart, Rome, Italy;Thyroid Disease Ambulatory and Thyroid Echointervention, Ospedale “ S. M. Goretti, ” Latina, Italy;Institute of Radiology Ospedale “ S. M. Goretti, ” Latina, Italy

关键词: Thyroid;    Multinodular goiter;    Levothyroxine therapy;    Pre-menopausal women;   

DOI  :  10.1507/endocrj.K10E-144

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(36)Cited-By(2)The levothyroxine suppressive efficacy in benign thyroid nodules treatment is well described in uninodular non-toxic goiter, whereas only few controlled trials enrolled patients with multinodular disease. The aim of the present study is to evaluate the short term effects of levothyroxine treatment in never treated, pre-menopausal women affected by thyroid multinodular disease. Seventy-one pre-menopausal women with thyroid multinodular disease, still presenting normal TSH levels, from Latina area were randomly assigned to a levothyroxine treated or control group. Biochemical and ultrasonography evaluations of thyroid were monitored at the enrolment and after 6, 12 and 24 months of treatment. In the levothyroxine treated group, after 1 year of treatment, thyroid and dominant nodule volume and number of nodules >0.5 mL significantly decreased from a median of 12.0 to 9.8 mL (p p p =0.007, p p 4 treatment in preventing thyroid and nodule volume and nodule numbers growth. These findings confirm the tendency of benign nodular disease toward progression and the efficacy of TSH suppression in preventing its evolution by means of removing the major growth factor for thyroid nodules still responsive to physiological stimuli.

【 授权许可】

Unknown