酵母DNAマイクロアレイを用いた環境水の評価

Chem-Bio Informatics Journal

村田-水上 里美³  岩橋 均³  北河 恵美子³  村田 善則¹  高見�? �?裕² 

[1] 独立行政法人�?産業�?術総合研究所;岐阜大学�?応用生物科学部�??環境微生物工学研究室;独立行政法人�?産業�?術総合研究所�?�?ヒューマンストレスシグナル研究センター

关键词: DNA microarray;    DNAマイクロアレイ;    hierarchical cluster analysis;    水質評価;    environmental water;    環境水;    yeast;    酵母;   

DOI  :  10.1273/cbij.6.29

学科分类：生物化学/生物物理

来源: Chem-Bio Informatics Society

【 摘 要 】

References(27)Cited-By(1)We propose a new method for the evaluation of environmental water by using DNA microarray technology.Twenty-one types of environmental waters were sampled from incineration processes, some factories, and various soils.We performed a comprehensive analysis by DNA microarray, and attempted to classify the environmental water samples by hierarchical cluster analysis.These water samples were classified into clusters from A to F together with chemicals and physical stress conditions.The water sample that grouped into cluster A caused protein denaturation and oxidative stress, but not mutagenesis.The water samples that grouped into cluster B caused protein denaturation.The water samples that grouped into cluster C caused mutagenesis, protein denaturation, and cell wall damage.The water samples that grouped into cluster D caused mutagenesis.The water samples that grouped into cluster E caused protein denaturation and oxidative stress.The water samples that grouped into cluster F caused oxidative stress.Consequently, the potential influences of environmental water could be estimated by hierarchical cluster analysis.

【 授权许可】

Unknown