Abrogation of Bronchial Eosinophilic Inflammation and Attenuated Eotaxin Content in Protease-Activated Receptor 2-Deficient Mice

Journal of Pharmacological Sciences

Naohiro Saito¹  Jiro Matsumoto¹  Masaki Tamiya¹  Takuya Hara¹  Yukio Hattori¹  Toshiaki Takizawa¹  Junichi Kawagoe¹  Toru Kanke¹ 

[1] Tokyo New Drug Research Laboratories II, Pharmaceutical Division, Kowa Company Ltd.

关键词: protease-activated receptor 2;    eosinophil;    eotaxin;   

DOI  :  10.1254/jphs.SCZ050138

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(27)Protease-activated receptor 2 (PAR2) belongs to the PAR family (PAR1 to PAR4), which is activated by serine proteases (trypsin, tryptase, etc.). In this study, we evaluated the role of PAR2 in allergic inflammation of airways using PAR2-deficient (PAR2−/−) mice. In wild- type mice, infiltration of eosinophils and high eotaxin content were found in bronchoalveolar lavage fluid (BALF) after ovalbumin (OA) sensitization and following challenge. In contrast, both OA-induced infiltration of eosinophils and increase of eotaxin content were abrogated in BALF from PAR2−/− mice. The activation of PAR2 might be essential in the production of eotaxin and consequential allergic inflammation in airways.

【 授权许可】

Unknown