Toll-Like Receptor (TLR) 2 and TLR4 Gene Expression in Canine Heart | Science Publications

American Journal of Animal and Veterinary Sciences

A. Linde¹  F. Blecha¹  T. Melgarejo¹ 

关键词: Innate immunity;    pattern recognition receptors;    cardiac and dog;   

DOI  :  10.3844/ajavsp.2007.6.10

学科分类：兽医学

来源: Science Publications

【 摘 要 】

Toll-like receptors (TLRs) are archetypal pattern recognition receptors of immediate importance for an efficacious innate immune response. TLRs exhibit marked differential tissue activity and their levels within a discrete cell type can be highly dynamic. Of 13 known mammalian paralogues, three TLRs have been identified in the dog. Although cardiac TLR expression has been reported in other species, this study is the first to present evidence that these innate immune receptors are expressed in the canine heart. Heart tissue samples from all four chambers were collected from healthy dogs immediately after euthanasia and stored at -80

【 授权许可】

Unknown