Early Onset of Reproductive Function in Female Rats Treated with a High-Fat Diet

Journal of Veterinary Medical Science

Tomoaki NAKADA²  Toru R. SAITO²  Makoto YOKOSUKA²  Nobuhiko NAKAO²  Wirasak FUNGFUANG¹ 

[1] Department of Zoology, Faculty of Science, Kasetsart University, Bangkok 10900, Thailand;Laboratory of Behavioral Neuroscience, Nippon Veterinary and Life Science University, Japan

关键词: adiponectin;    female rats;    high-fat diet;    leptin;    leptin mRNA;   

DOI  :  10.1292/jvms.12-0276

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(3)Puberty onset in mammals is tightly coupled to the animal’s nutritional and metabolic state. In the present study, we evaluated the effects of a high-fat diet on leptin and adiponectin levels, leptin mRNA expression and puberty onset in female rats. On day 21, female rats were divided into 2 groups, normal food (NF) and high-fat food (HF). The HF group showed a significantly earlier (PPP<0.05) than those fed the NF food, whereas the serum leptin and adiponectin levels and leptin mRNA expression were not significantly different between the NF and HF groups. We speculate that the fat-induced nutritional imbalance in young females may lead to neuroendocrine dysfunction during adolescence.

【 授权许可】

Unknown