Association between beta cell function and future glycemic control in patients with type 2 diabetes

Endocrine Journal

Akira Shimada²  Kumiko Tanaka³  Yoshifumi Saisho³  Takayuki Abe¹  Hiroshi Itoh³  Kinsei Kou³  Toshihide Kawai³ 

[1] Center for Clinical Research, Keio University School of Medicine, Tokyo 160-8582, Japan;Department of Internal Medicine, Saiseikai Central Hospital, Tokyo 108-0073, Japan;Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan

关键词: Type 2 diabetes;    Glycated hemoglobin;    Beta cell function;    C-peptide;   

DOI  :  10.1507/endocrj.EJ12-0416

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(23)Cited-By(1)The aim of this study was to clarify the association between C-peptide immunoreactivity (CPR), a marker of beta cell function, and future glycemic control in patients with type 2 diabetes.We conducted a retrospective analysis of 513 consecutive patients with type 2 diabetes who were admitted to our hospital between 2000 and 2007 and followed up for 2 years.Serum and urinary CPR levels were measured during admission, and CPR index was calculated as the ratio of CPR to plasma glucose.The associations between these markers at baseline and glycemic control after 2 years were assessed by means of logistic regression models.After 2 years, 167 patients (32.6%) showed good glycemic control (HbA1c P = 0.001) among CPR indices.Multivariate analyses showed consistent results (OR 1.23, 95%CI 1.03-1.48, P = 0.021).In conclusion, preserved beta cell function at baseline was associated with better glycemic control thereafter in patients with type 2 diabetes.

【 授权许可】

Unknown