Shedding of Rubella Virus among Infants with Congenital Rubella Syndrome Born in Tokyo, Japan, 2013–2014

Japanese Journal of Infectious Diseases

Akemi Kai¹  Yuuko Iwashita¹  Masami Sumitomo¹  Aya Kayebeta¹  Noriko Hayata¹  Masayuki Kurita¹  Narumi Tahara¹  Tetsuya Akiba¹  Terue Okazaki¹  Tokuko Tsunoda¹  Naomi Seki¹  Konomi Murauchi¹  Yukinao Hayashi¹  Michiya Hasegawa¹  Yoshiyuki Sugishita¹ 

[1] Tokyo Metropolitan Institute of Public Health

关键词: congenital rubella;    CRS;    PCR method;    throat swab;    virus shedding period;   

DOI  :  10.7883/yoken.JJID.2015.316

学科分类：传染病学

来源: National Institute of Infectious Diseases

【 摘 要 】

References(12)Rubella is usually a mild illness, with febrile rash being its main symptom. However, serious consequences of rubella infection can result when the infection occurs during the early stages of pregnancy. After the occurrence of a rubella outbreak in Japan that was observed from 2012 to 2013, 45 infants were reportedly born with congenital rubella syndrome (CRS). We prospectively followed the 15 CRS cases reported in Tokyo to determine the virus shedding periods by using nested reverse transcriptase-polymerase chain reaction to detect rubella virus genes. Throast swabs were used for virus detection. The virus shedding period was measured from birth until the time when the sample last tested positive followed by 2 consecutive negative samples. Kaplan-Meier method was used to estimate the proportion of cases remaining positive for rubella virus genes over time. The proportion of CRS cases shedding virus dropped steadily after birth, dropping to 33.8% at 6 months and 16.9% at 12 months. Our findings also suggested that the earlier the mother's onset of rubella during pregnancy, the longer the infant remained positive. Based on our findings, we believe that infants with CRS should be monitored for rubella virus shedding until 1 year of age.

【 授权许可】

Unknown