ミオグロビン、ヘモグロビンにおける二次構造ブレイカとヘアピン構�?�のメカニズム

Chem-Bio Informatics Journal

今井 賢一郎¹  �? 敏之¹  美宅 成樹¹  園山 正史¹  朝川 直行¹ 

[1] 名古屋大学�??大学院�??工学研究科

关键词: secondary structure;    二次構�?�;    all-α protein;    二次構�?�ブレイカ;    charge symmetry;    水溶性タンパク質;    prediction;    両親媒�?�;    bioinformatics;    電荷分布;    構�?�予測;   

DOI  :  10.1273/cbij.5.65

学科分类：生物化学/生物物理

来源: Chem-Bio Informatics Society

【 摘 要 】

References(26)Cited-By(1)Secondary structure breakers, particularly hairpin structures, impose strong limitations on the global structure of a protein. Three kinds of secondary structure breakers (proline, glycine and amphiphilic residues) were studied in myoglobin and hemoglobin, which are typical all-α type proteins. Secondary structure breakers were located as predicted in about two thirds of the interhelical loops. Charge symmetry analysis provided evidence that high charge symmetry drives the formation of hairpin structures. Based on this information about breakers and hairpin structures, the possibility of folding a protein in silico is discussed.

【 授权许可】

Unknown