Impact of Renal Function or Folate Status on Altered Plasma Homocysteine Levels in Hypothyroidism

Endocrine Journal

Oya BAYINDIR³  Isil MUTAF³  Zuhal PARILDAR³  Bilgin ÖZMEN²  Nevbahar TURGAN¹  Dilek ÖZMEN³ 

[1] Department of Biochemistry, Ege University School of Medicine;Department of Endocrinology, Celal Bayar University School of Medicine;Department of Clinical Biochemistry, Ege University School of Medicine

关键词: Hypothyroidism;    Homocysteine;    Cystatin C;    Renal function;    Folate status;   

DOI  :  10.1507/endocrj.53.119

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(39)Cited-By(10)Hyperhomocysteinemia is an independent risk factor for coronary, peripheral and cerebrovascular diseases. Moderately elevated total homocysteine (tHcy) levels have been reported in patients with overt hypothyroidism. Plasma tHcy concentration is affected by several physiological factors and is elevated under conditions of impaired folate and cobalamin status and in renal failure. The aim of this study was to assess plasma tHcy concentrations and to evaluate the role of potential determinants of plasma tHcy levels in hypothyroid patients. Fasting plasma tHcy, serum homocysteine-related vitamins folate and vitamin B12, serum cystatin C (CysC) and creatinine, were determined in 22 hypothyroid patients and compared with 25 healthy control subjects. Creatinine clearance (CCr) was calculated using the Cockroft-Gault formula. Plasma tHcy levels were determined by HPLC with fluorescence detection and serum CysC by automated particle enhanced immunoturbidimetry. Plasma tHcy, creatinine levels were significantly higher, and serum CysC levels, and creatinine clearance values were lower in hypothyroid patients than in control subjects. Folate levels were lower in hypothyroidic group compared to the control group. There were no differences in vitamin B12 levels between hypothyroid and control groups. Positive correlation was noted between tHcy and creatinine levels in hypothyroid patients (r = 0.596); however, an inverse correlation was found between tHcy and folate levels (r = -0.705) in hypothyroid patients. In conclusion, tHcy was increased in hypothyroidism, and this increase was more strongly associated with changes in serum folate than in serum creatinine and CysC, suggesting an altered folate status.

【 授权许可】

Unknown