期刊论文详细信息
Journal of Pharmacological Sciences | |
Monitoring Expression of Cytochrome P450 Genes During Postischemic Rat Liver Reperfusion Using DNA Microarrays | |
Koichi Ishikawa2  Yukimoto Ishii1  Yasuo Takahashi3  Satoshi Asai3  Yayoi Nishida3  | |
[1] Department of Surgery, Nihon University School of Medicine;Department of Pharmacology, Nihon University School of Medicine;Division of Genomic Epidemiology & Clinical Trials, Advanced Medical Research Center, Nihon University School of Medicine | |
关键词: cytochrome P450; postischemic liver reperfusion; gene expression; | |
DOI : 10.1254/jphs.RC0040040 | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(10)Cited-By(4)We investigated the expression of 50 cytochrome P450 (CYP) genes in the postischemic reperfused rat liver using a DNA microarray. Thirteen CYPs showed absent expression in all experiments and 2 CYPs were induced by pentobarbital, which was used as an anesthetic. Eight of the remaining 35 CYPs showed significantly decreased expression following ischemia-reperfusion. Monitoring CYP expression may be a powerful approach for elucidation of pathways regulating drug metabolism that may be involved in postischemic reperfusion liver injury.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201911300378246ZK.pdf | 367KB | download |