Monitoring Expression of Cytochrome P450 Genes During Postischemic Rat Liver Reperfusion Using DNA Microarrays

Journal of Pharmacological Sciences

Koichi Ishikawa²  Yukimoto Ishii¹  Yasuo Takahashi³  Satoshi Asai³  Yayoi Nishida³ 

[1] Department of Surgery, Nihon University School of Medicine;Department of Pharmacology, Nihon University School of Medicine;Division of Genomic Epidemiology & Clinical Trials, Advanced Medical Research Center, Nihon University School of Medicine

关键词: cytochrome P450;    postischemic liver reperfusion;    gene expression;   

DOI  :  10.1254/jphs.RC0040040

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(10)Cited-By(4)We investigated the expression of 50 cytochrome P450 (CYP) genes in the postischemic reperfused rat liver using a DNA microarray. Thirteen CYPs showed absent expression in all experiments and 2 CYPs were induced by pentobarbital, which was used as an anesthetic. Eight of the remaining 35 CYPs showed significantly decreased expression following ischemia-reperfusion. Monitoring CYP expression may be a powerful approach for elucidation of pathways regulating drug metabolism that may be involved in postischemic reperfusion liver injury.

【 授权许可】

Unknown