Elevated Serum Levels of S100 Calcium Binding Protein A8 (S100A8) Reflect Disease Severity in Canine Atopic Dermatitis

Journal of Veterinary Medical Science

Jin-Sik OH³  Hwa-Young YOUN¹  Kyung-Sun KANG²  Ji-Won JUNG²  Yong-Soon LEE²  Cheol-Yong HWANG¹  Tae-Ho CHUNG¹ 

[1] Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University;Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National University;BioNote Inc.

关键词: atopic dermatitis;    canine;    ELISA;    monoclonal antibody;    S100A8;   

DOI  :  10.1292/jvms.09-0423

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(25)Cited-By(6)A monoclonal antibody to canine S100 calcium binding protein A8 (S100A8) was developed to determine the association between S100A8 and the disease severity of canine atopic dermatitis. Serum S100A8 concentrations were studied in dogs with canine atopic dermatitis (n=213) and healthy dogs (n=213). Statistical correlations between these indices and atopic dermatitis activity were established, and dermatitis severity was assessed according to the CADESI score. Serum S100A8 concentrations were measured with an enzyme-linked immunosorbent assay (ELISA). S100A8 serum levels were significantly higher in canine atopic dermatitis patients than in healthy dogs. A strong positive correlation was identified between S100A8 levels and canine atopic dermatitis patients. Our findings suggested that S100A8 is actively involved in the pathogenesis and clinical picture of canine atopic dermatitis.

【 授权许可】

Unknown