Effect of onion extract on corneal haze suppression after air assistedlamellar keratectomy

Journal of Veterinary Medical Science

Je Kyung SEONG²  Euiri LEE¹  Sang Wan PARK¹  Soohyun KIM¹  Hyunwoo NOH¹  Jong Whi KIM²  Kangmoon SEO¹  Sungwon PARK¹  Young Woo PARK¹ 

[1] Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151�?742, Korea;Department of Veterinary Biomedical Science and Research institute for Veterinary Science, College of Veterinary Medicine, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151�?742, Korea

关键词: α-SMA;    canine eye;    corneal haze;    onion extract;    TGF-β1;   

DOI  :  10.1292/jvms.15-0455

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)This study evaluated the effect of onion extract on corneal haze suppressionafter applying the air assisted lamellar keratectomy. The air assisted lamellarkeratectomy was performed on 24 canine eyes. They were treated with an artificial tear(group C), prednisolone acetate (group P), onion extract (group O) and TGF-β1 (group T)three times per day from 7 to 28 days after the surgery. Corneal haze occurred on the alleyes and was observed beginning 7 days after the surgery. The haze was significantlydecreased in groups P and O from day 14 compared with the group C using the clinical(group P; P=0.021, group O; P=0.037) and objectiveevaluation method (group P; P=0.021, group O; P=0.039).In contrast, it was significantly increased in group T from day 14 compared with group Cbased on the clinical (P=0.002) and objective evaluation method(P<0.001). Subsequently, these eyes were enucleated aftereuthanasia, and immunohistochemistry with α-SMA antibodies was done. The total greenintensity for α-SMA was significantly more expressed in group T and significantly lessexpressed in groups P and O than in group C. Onion extract could have potential as atherapeutic in preventing corneal haze development by suppressing the differentiation offibroblasts into myofibroblasts.

【 授权许可】

Unknown