Effect of iron supplementation on mental and motor development in children: systematic review of randomised controlled trials

Public Health Nutrition

HPS Sachdev¹  Penelope Nestel¹  Tarun Gera¹ 

关键词: Anaemia;    Cognition;    Iron;    deficiency;    Iron supplementation;    Mental development;    Meta-analysis;    Motor development;    Randomised controlled trials;   

DOI  :  10.1079/PHN2004677

学科分类：卫生学

来源: Cambridge University Press

【 摘 要 】

ObjectiveTo evaluate the effect of iron supplementation on mental and motor development in children through a systematic review of randomised controlled trials (RCTs).Data sourcesElectronic databases, personal files, hand search of reviews, bibliographies of books, abstracts and proceedings of international conferences.Review methodsRCTs with interventions that included oral or parenteral iron supplementation, fortified formula milk or cereals were evaluated. The outcomes studied were mental and motor development scores and various individual development tests employed, including Bayley mental and psychomotor development indices and intelligence quotient.ResultsThe pooled estimate (random effects model) of mental development score standardised mean difference (SMD) was 0.30 (95% confidence interval (CI) 0.15 to 0.46, P < 0.001; P < 0.001 for heterogeneity). Initial anaemia and iron-deficiency anaemia were significant explanatory variables for heterogeneity. The pooled estimate of Bayley Mental Development Index (weighted mean difference) in younger children (

【 授权许可】

Unknown