The Effect of a Prophylactic Dose of Ibuprofen on Plasma Level of Interleukin 1, Interleukin 6 and Tumor Necrosis Factor-Alpha in a 1500 m Running Practice | Science Publications

American Journal of Applied Sciences

Ali S. Khachaki¹  Gholamreza Sepehri¹  Ehsan Sepehri¹  Mohammad Pourranjbar¹  Ghollam-Reza Moshtaghi-Kashanian¹ 

关键词: Plasma cytokines;    Ibuprofen;    Running race;    strenuous exercise;    Tumor Necrosis Factor Alpha (TNF- α);    Delayed-Onset Muscle Soreness (DOMS);    C-Reactive Protein (CRP);    Enzyme-Linked Immunosorbent Assay (ELISA);    Non-Steroidal Anti-Inflammatory Drugs (NSAIDs);    inflammatory cytokines;   

DOI  :  10.3844/ajassp.2011.50.54

学科分类：自然科学（综合）

来源: Science Publications

【 摘 要 】

Problem statement: there are controversies about the effects of anti-inflammatory drugs on exercised induced changes on plasma cytokines in untrained male athletes, so the primary purpose of this study was to measure the influence of a prophylactic dose of ibuprofen use on plasma cytokines during a 1500 m running race. Approach: Subjects were 10 untrained male Medical University students who consumed 400 mg ibuprofen two hours before the 1500 m running practice and 10 controls that competed in the race but avoided ibuprofen and all other medications. Blood samples were collected before, 1h and 24 h following the 1500 m exercise bout to measure plasma concentrations of interleukin-1 beta (IL-1β ), interleukin-6(IL-6) and tumor necrosis factor alpha (TNF- α ). Results: There were not any significant differences between plasma concentration of IL-1β, IL-6 and TNF- α during the study period. Also the data showed that there were not any significant differences between plasma level of IL-1β, IL-6 and TNF- α in ibuprofen and control group during the study period. Conclusions/Recommendation: Our result showed that a prophylactic dose of ibuprofen did not affect acute inflammatory cytokines levels (IL-1β, IL-6 and TNF- α) in untrained healthy young males. So the etiology of the muscle soreness in athletes actively participating in sport races seems to be independent of inflammatory processes.

【 授权许可】

Unknown