Spontaneous Remission of Functioning Pituitary Adenomas without Hypopituitarism following Infarctive Apoplexy: Two Case Reports

Endocrine Journal

Tamotsu MIKI¹  Jo HARAOKA¹  Hiroshi NISHIOKA¹ 

[1] Department of Neurosurgery, Tokyo Medical University

关键词: Acromegaly;    Pituitary adenoma;    Pituitary apoplexy;    Pituitary infarction;    Prolactinoma;   

DOI  :  10.1507/endocrj.52.117

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(19)Cited-By(14)Functioning pituitary adenomas may exhibit spontaneous remission after pituitary apoplexy usually in association with hypopituitarism. We report two patients who presented with sudden headache and double vision, showed a ring-enhanced sellar tumor on MRI, underwent transsphenoidal surgery that revealed a coagulation necrotic adenoma without massive hemorrhage, and showed normal pituitary function after the surgery. Definitive diagnoses were made based on immunohistochemistry of the necrotic cells. The findings were consistent with the presence of selective infarct of a GH adenoma and a prolactinoma that had led to remission of acromegaly and menstrual disturbance, respectively, without pituitary insufficiency. In contrast to hemorrhagic apoplexy, infarctive apoplexy tends to affect only the tumor and thus presents with mild symptoms and lack pituitary deficiencies.

【 授权许可】

Unknown