Different Effects of Pueraria mirifica, a Herb Containing Phytoestrogens, on LH and FSH Secretion in Gonadectomized Female and Male Rats

Journal of Pharmacological Sciences

Gen Watanabe¹  Wichai Cherdshewasart²  Suchinda Malaivijitnond²  Patthama Kiatthaipipat²  Kazuyoshi Taya¹ 

[1] Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology;Primate Research Unit, Department of Biology, Faculty of Science, Chulalongkorn University

关键词: Pueraria mirifica;    phytoestrogen;    LH;    FSH;    vaginal cytology;   

DOI  :  10.1254/jphs.FPJ04029X

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(43)Cited-By(41)To investigate the effect of Pueraria mirifica (P. mirifica) containing phytoestrogens on reproductive systems, both sexes of rats were gonadectomized and treated orally with 0, 10, 100, and 1,000 mg/kg BW per day of P. mirifica suspended in water (abbreviated as P-0, P-10, P-100, and P-1000), respectively. The treatment schedule was separated into 3 periods: pre-treatment, treatment, and post-treatment. The duration for each period was 14 days. Blood samples were taken once a week. Serum LH and FSH levels were significantly increased within 1 week after gonadectomy; and there were no changes after administration of P-0, P-10, and P-100. However, the increase of LH levels in both sexes and FSH levels in females were attenuated within 1 week after P-1,000 treatment. The attenuation of LH levels in males was smaller than that of females. The decrease of gonadotropin levels was recovered within 1 week in males and 2 weeks in females, respectively, during the post-treatment period. The increase of uterine weight and vaginal cornification were observed in female rats treated with P-100 and P-1,000, whereas only the increase of epididymis weight was found in male rats treated with P-1,000. From this study, it can be concluded that P. mirifica can influence the reproductive functions in both sexes of rats, but the response in females is greater than in males.

【 授权许可】

Unknown