期刊论文详细信息
Journal of Pharmacological Sciences
A New Frontier in Epilepsy: Novel Antiepileptogenic Drugs
Masashi Sasa1 
[1] Hiroshima University, Japan
关键词: epilepsy;    ictogenesis;    epileptogenesis;    antiepileptic drugs;    levetiracetam;   
DOI  :  10.1254/jphs.CPJ06010X
学科分类:药学
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society
PDF
【 摘 要 】

References(62)Cited-By(23)Epilepsy is a hetergenous syndrome characterized by recurrently and repeatedly occurring seizures. Although able to inhibit the epileptic seizures, the currently available antiepileptic drugs (AEDs) have no effects on epileptogenesis. Such AEDs should be classified as drugs against ictogenesis, which are transient events in ion and/or receptor-gated channels related with triggering to evoke seizures. Epileptogenesis involves long-term and histological/biochemical/physiological alterations formed in brain structures over a long period, ranging from months to years. This review focuses on the effects of AEDs on epileptogenesis and novel candidates of antiepileptogenic drugs using a genetically defined epilepsy model animal, the spontaneous epileptic rat (SER).

【 授权许可】

Unknown   

【 预 览 】
附件列表
Files Size Format View
RO201911300362449ZK.pdf 844KB PDF download
  文献评价指标  
  下载次数:13次 浏览次数:9次