Intracerebroventricular Injection of Microglia Protects Against Focal Brain Ischemia

Journal of Pharmacological Sciences

Daijiro Yanagisawa¹  Daiju Tsuchiya¹  Masatoshi Inden¹  Takashi Taniguchi¹  Junko Nakata¹  Kazuyuki Takata¹  Yoshihisa Kitamura¹ 

[1] Department of Neurobiology, Kyoto Pharmaceutical University

关键词: microglia;    neuroprotection;    focal brain ischemia;   

DOI  :  10.1254/jphs.94.203

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(44)Microglia are macrophage-like phagocytic cells in the brain parenchyma. However, microglial function after neurodegeneration is not fully understood. In this study, occlusion of the middle cerebral artery (MCA) and reperfusion caused massive neuronal loss in the rat cerebral cortex and striatum after 3 days. When exogenous microglia were microinjected into the intracerebroventricle during MCA occlusion, neurodegenerative areas significantly decreased. At that time, migrated microglia were detected in the ischemic lesion. These results suggest that exogenous microglia can migrate into brain parenchyma and then protect against neurodegeneration induced by MCA occlusion and reperfusion.

【 授权许可】

Unknown