In vitro interferon gamma production in mice vaccinated with 麓Mycobacterium habana麓 against Mycobacterium tuberculosis antigens

Revista Cubana de Medicina Tropical

Hernández-Pando, Rogelio¹  Montoro Cardoso, Ernesto²  Valdés Hernández, Iliana² 

[1] Instituto de Ciencias Médicas y Nutrición Salvador Zubirán, México DF, México;Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba

关键词: tuberculosis;    IFN gamma;    ´Mycobacterium habana´;    vaccine;   

DOI  :  

学科分类：传染病学

来源: SciELO

【 摘 要 】

Introduction: development of new antituberculosis vaccines requires the characterization of the cell-mediated immune responses induced by mycobacterial antigens. Objective: to determine the immunogenic potential of ´Mycobacterium habana´ TMC-5135 when using subcutaneous vaccine in Balb/c mice. Methods: in this study, Balb/c mice were inoculated subcutaneously with live ´Mycobacterium habana´ TMC-5135. The production of IFN gamma in cell suspensions obtained from the lungs, the spleen and the lymph nodes after stimulation with mycobacterial antigens Ag85b or culture filtrate antigens (CFA) was recorded. Results: the production of IFN gamma after stimulation with CFA and Ag85b was higher in mice vaccinated with ´M. habana´ than in animals immunized with BCG. Conclusions: these results encourage new research on ´M. habana´ as vaccinal candidate against tuberculosis.

【 授权许可】

Unknown