Risk factors for neurodevelopmental deficits in congenital hypothyroidism after early substitution treatment

Endocrine Journal

Changlian Zhu³  Dehua Zhao²  Jun Wang³  Xinxia Wang⁴  Hezhou Li⁴  Zhan Zhang²  Hongqi Feng¹  Kaiming Huo³  Xiaoyang Wang³ 

[1] Department of Child Healthcare, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Neonatal Screening Center of Henan Province, Zhengzhou University, Zhengzhou 450052, China;Department of Pediatrics, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China;Imaging Center, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

关键词: Congenital hypothyroidism;    Neonatal screening;    Developmental quotient;   

DOI  :  10.1507/endocrj.K10E-384

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(30)Cited-By(2)Neurodevelopment in children with congenital hypothyroidism who receive early treatment is generally good.However, subtle neurological deficits still exist in some patients.The aim of this investigation was to evaluate factors that may influence neurodevelopmental outcome in congenital hypothyroidism patients.The developmental quotient (DQ) of 155 children with congenital hypothyroidism was evaluated at 24 months of age, using Gesell Developmental Schedules (GDS), and compared with that of 310 healthy controls.Mean DQ scores in congenital hypothyroidism patients were 7.5 points lower for adaptive behavior than in control patients (p p 4 at diagnosis or exhibited a longer thyroid stimulating hormone (TSH) normalization time had lower adaptive behavior scores (p p < 0.01).Neurodevelopmental deficits in children with congenital hypothyroidism correlate with the severity of congenital hypothyroidism, TSH normalization time, and parental socioeconomic status.

【 授权许可】

Unknown