Effect of Ginseng radix on c-Fos Expression in the Hippocampus of Streptozotocin-Induced Diabetic Rats

Journal of Pharmacological Sciences

Mi-Hyeon Jang²  Min-Chul Shin²  Chang-Ju Kim²  Taeck-Hyun Lee²  Ee-Hwa Kim¹  Hyun-Kyung Chang²  Young-Pyo Kim² 

[1] Department of Meridianology, College of Oriental Medicine, Semyung University;Department of Physiology, College of Medicine, Kyung Hee University

关键词: Ginseng radix;    streptozotocin-induced diabetes;    c-Fos;   

DOI  :  10.1254/jphs.91.149

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(10)Aqueous extracts of Ginseng radix have traditionally been used in the treatment of diabetes mellitus. In the present study, the effect of Ginseng radix on c-Fos expression in the hippocampus of streptozotocin (STZ)-induced diabetic rats was investigated via immunohistochemistry. Decreased c-Fos expression in the CA regions of the hippocampus was observed in STZ-induced diabetes, and administration of Ginseng radix enhanced the STZ-induced inhibition of c-Fos expression both dose- and duration-dependently. These results suggest that hyperglycemia-induced suppression of Fos expression may trigger the diabetes-induced disruption of hippocampal information processing and that Ginseng radix may alleviate this diabetes-induced disturbance in hippocampal functions.

【 授权许可】

Unknown