Inflammatory activity of pelvic ileal pouches mucosa in asymptomatic patients

Revista Brasileira de Coloproctologia

Leal, Raquel Franco²  Ayrizono, Maria de Lourdes Setsuko²  Coope, Andressa²  Ângelo, Sandro Nunes²  Coy, Cláudio Saddy Rodrigues²  Milanski, Marciane²  Velloso, Lício Augusto¹  Fagundes, João José² 

[1] UNICAMP;Universidade Estadual de Campinas

关键词: Ulcerative colitis;    familial adenomatous polyposis;    ileal pouch;    pouchitis;    cytokines.;   

DOI  :  10.1590/S0101-98802008000400006

学科分类：心脏病和心血管学

来源: Sociedade Brasileira de Coloproctologia

【 摘 要 】

Pouchitis after total retocolectomy is the most common complication in ulcerative colitis (UC). The immunological mechanisms involved in the genesis of pouchitis are unclear.PURPOSE: To evaluate STAT-1 activation and IFN-ã expression in normal ileal pouch mucosa.METHODS: Eighteen asymptomatic patients submitted to total retocolectomy and J pouch, were evaluated, being nine with UC and nine with FAP. The activation of STAT-1 and expressions of the cytokine were determined by immunoblot of total protein extracts from pouch mucosal biopsies.RESULTS: STAT-1 activation was increased in UC, when compared to FAP and controls. Higher levels of IFN-γ expression were observed in UC when compared to control group, but was similar to FAP.CONCLUSIONS: These findings could explain a higher susceptibility to this inflammatory complication in UC when compared to FAP, which may be similar to UC disease.

【 授权许可】

CC BY-NC