Short-Term Performance of Mitral Valve Replacement with Porcine Bioprosthetic Valves in Dogs

Journal of Veterinary Medical Science

Aiko SODA¹  Kazuaki TAKASHIMA²  Ryou TANAKA¹  Yoshihisa YAMANE² 

[1] Department of Veterinary Surgery, Faculty of Agriculture, Tokyo University of Agriculture and Technology;Animal Clinical Research Foundation

关键词: bioprosthetic valve;    canine cardiopulmonary bypass;    mitral regurgitation;    mitral valve replacement;   

DOI  :  10.1292/jvms.69.793

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(31)Cited-By(3)Porcine bioprosthetic valves cross-linked with glutaraldehyde and polyepoxy compound were newly developed for mitral valve replacement (MVR) in dogs. Five beagle dogs were performed a left thoracotomy and underwent MVR using the porcine bioprosthetic valves during cardiopulmonary bypass (CPB). A vein catheter inserted into right atrium and a vent catheter inserted into the right ventricle to drain. The hemodynamic conditions of CPB were excellent during surgery. The left atrial pressure was measured before and after MVR; there was no significant difference and it was normal. Thrombosis and the prosthetic valve regurgitation were not observed one week after MVR. Pressure half time (PHT) prolonged significantly (P<0.05) from 31.40 ± 4.0 msec presurgery to 99.20 ± 19.4 msec at seven days after MVR, although it indicated the normal range as the bioprosthetic valve. The symptom of the prosthetic valve failure was not observed. This study indicated that the MVR using porcine bioprosthetic valves under CPB might have been effective in dogs as a short-term evaluation.

【 授权许可】

Unknown