Inhibitory Effect of Ginger Extract on Candida albicans | Science Publications

American Journal of Applied Sciences

Zahra Atai¹  Manijeh Atapour¹  Maryam Mohseni¹ 

关键词: zingiber offcinale;    antifungal activity;    Candida albicans;   

DOI  :  10.3844/ajassp.2009.1067.1069

学科分类：自然科学（综合）

来源: Science Publications

【 摘 要 】

Problem statement:The fungal infections could be life-threatening in immunocompromisedpatients. Candida albicans is the most frequent fungi in the oral cavity. Approach: The first step fortreatment could be done using topical antifungal agents. Nystatine is a choice for mentioned usage butthere are some problems in its using including: unfavorite taste, frequency of usage, etc. Finding betterreplacements is the subject of many studies. Results: This study was carried out to find an alternativefor Nystatine. The study was designed based on laboratory investigations to investigate the antifungalactivity of zingiber offcinale (Ginger) on Candida albicans. Candida albicanse (PTCC 5027,ATCC10231) was obtained from Iranian microbial collection and was confirmed by Germ Tubeformation test. Ethanolic ginger extract was prepared. The antifungal activity of the extract wasdetermined using Agar dilution and disc diffusion techniques. Data were analyzed by ANOVA test.Conclusion/Recommendations:The results showed that the ethanolic extract was effective onCandida albicans (2 mg mL^-1) at the concentration of 1:5. The study indicates that ginger extractmight have promise in treatment of oral candidiasis.

【 授权许可】

Unknown