Antidepressant-like Effect of Fuzi Total Alkaloid on Ovariectomized Mice

Journal of Pharmacological Sciences

Bingjin Li¹  Fang Tang¹  Lei Liu¹  Dongyuan Shao¹  Ranji Cui¹  Hui Zhao¹  Yang Zhou¹  Liang Wang¹  Xiulan Jiang¹  Yuxin Li¹ 

[1] Laboratory of Neuroscience, Physiology, School of Life Sciences, Northeast Normal University, China

关键词: alkaloid;    ovariectomized mouse;    forced swimming;    BDNF (brain-derived neurotrophic factor);   

DOI  :  10.1254/jphs.12163FP

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(35)Cited-By(6)Supplementary materials(1)Recent studies in vivo and vitro have shown that Fuzi polysaccharide has an antidepressant-like effect. Polysaccharide and total alkaloid are the two most important components of Fuzi. However, little is known about the antidepressant-like effect of Fuzi total alkaloid. To investigate the antidepressant-like effect of Fuzi total alkaloid, behavioral studies were performed in the open field test and forced swimming test. Repeated intragastric administration of Fuzi total alkaloid for 7 days (10 mg/kg) to normal mice decreased immobility time compared to the vehicle group. Furthermore, repeated administration of Fuzi total alkaloid (10 or 30 mg/kg) to ovariectomized mice also decreased immobility time in a dose-dependent manner. However, these antidepressant-like behavioral effects were not simply due to locomotor hyperactivity. Further experiments showed that Fuzi total alkaloid enhanced the ratio of phospho-CREB/CREB (cAMP response element-binding) and BDNF (brain-derived neurotrophic factor) protein level in the frontal cortex and hippocampus in ovariectomized mice but not in normal mice. These results indicate that the CREB-BDNF pathway may be involved in the antidepressant-like effect of Fuzi total alkaloid in ovariectomized mice.

【 授权许可】

Unknown