Beneficial effects of citrus juice fermented with Lactobacillus plantarum YIT 0132 on atopic dermatitis: results of daily intake by adult patients in two open trials

Bioscience of Microbiota, Food and Health

Daisuke NOZAKI¹  Kouji MIYAZAKI⁴  Takayuki NAGINO⁴  Keiko KAMACHI²  Naomi HARIMA-MIZUSAWA⁴  Shinichiro NAKAMURA³  Yuji YOKOMIZO³  Akira TANAKA²  Tatsuo UETAKE³  Mitsuyoshi KANO⁴ 

[1] Yakult Honsha Co., Ltd., 1-19 Higashi Shimbashi 1-chome, Minato-ku, Tokyo 105-8660, Japan;Kagawa Nutrition University, 3-24-3 Komagome, Toshima-ku, Tokyo 170-8481, Japan;RIKEN Innovation Center, Nakamura Laboratory, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan;Yakult Central Institute, 5-11 Izumi, Kunitachi-shi, Tokyo 186-8650, Japan

关键词: Lactobacillus plantarum;    citrus juice;    atopic dermatitis;    Skindex-16;    quality of life;    immunoglobulin E;    eosinophil cationic protein;   

DOI  :  10.12938/bmfh.2015-010

学科分类：生物科学（综合）

来源: Nihon Bifizusukin Senta / Japan Bifidus Foundation

【 摘 要 】

References(26)This study aimed to examine whether daily intake of citrus juice containing heat-killed Lactobacillus plantarum YIT 0132 (LP0132-fermented juice) alleviates symptoms of atopic dermatitis. This was a natural extension of our previous study in which LP0132 was shown to enhance IL-10 production in vitro and LP0132-fermented juice was found to alleviate symptoms and enhance quality of life (QOL) in patients with Japanese cedar pollinosis. In two open trials, Trial 1 and Trial 2, 32 and 18 adult patients with mild to moderate atopic dermatitis consumed LP0132-fermented juice for 8 weeks. Skin conditions and QOL were subjectively evaluated using Skindex-16 before intake of the juice (Pre-treatment), 8 weeks after starting intake (Treatment) and 8 weeks after termination of intake (Post-treatment). Blood parameters were also analyzed. Comparison of the Treatment and Post-treatment time points with the Pre-treatment time point revealed significant reductions in the Skindex-16 overall score and the 3 domain subscores (symptoms, emotions, and functioning domains) in both trials. Moreover, blood levels of eosinophil cationic protein (ECP), total immunoglobulin E (IgE) and specific IgEs for Japanese cedar and cypress pollen were significantly attenuated in Trial 2. The findings suggest that daily intake of citrus fermented juice containing heat-killed LP0132 has beneficial effects on symptoms and QOL in patients with mild to moderate atopic dermatitis due to an immunomodulatory effect via attenuation of IgE and ECP.

【 授权许可】

Unknown