Clinical Utility of Thyroid Ultrasonography in the Diagnosis of Congenital Hypothyroidism

Endocrine Journal

TOSHIYUKI YASUDA⁴  KAZUNORI SANAYAMA⁵  TOMOYUKI WATANABE⁴  HIROKAZU SATO¹  HIROAKI INOMATA²  HIROMASA NODA³  KUNIO WATAKI⁴  HIROO NIIMI⁴  HISASHI OHNISHI³ 

[1] Department of Endocrinology, Chiba Children's Hospital;Department of Pediatrics, Ichihara Hospital of Teikyo University, School of Medicine;Department of Pediatrics, Funabashi Central Hospital;Department of Pediatrics, School of Medicine, Chiba University;Department of Pediatrics, Narita Red Cross Hospital

关键词: Thyroid ultrasonography;    Congenital hypothyroidism;    Newborn screening;   

DOI  :  10.1507/endocrj.49.293

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(13)Cited-By(13)To determine the clinical utility of thyroid ultrasonography in the diagnosis of congenital hypothyroidism (CH) before initiation of therapy, ultrasonographic images of the thyroid gland with a high-resolution transducer were obtained in 204 healthy infants aged from newborn to 12 months (Group A), and 174 infants suspected of having CH detected by neonatal mass screening (Group B). The thyroid gland was imaged by transverse scanning at the anatomic site of the thyroid gland. The maximal width of thyroid on the transverse section in the normal location was measured. By comparing with the normal thyroid gland size and location obtained from Group A, 174 infants of Group B were divided into four subgroups: 1) Normal in size (n=117), 2) Enlarged (n=33), 3) Small (n=1) and 4) Invisible in the normal location (n=23). They were compared with the final diagnoses based on the results of chemical laboratory data and scintigraphic findings. The sensitivity and the specificity for the presence or absence of the thyroid gland in the normal location were 96% (22/23) and 99% (150/151), respectively. Both subgroups of normal and enlarged sized gland included healthy infants (false positive), transient hyperthyrotropinaemia, transient hypothyroidism and CH due to dyshormonogenesis. We conclude that ultrasonography is useful for determining the presence or absence of the thyroid gland in the normal location, whereas normal and enlarged sized glands require further examination to complete the diagnosis.

【 授权许可】

Unknown