Cardiovascular Reflex Mechanisms by Topical Instillation of Capsaicin and Distilled Water into the Larynx in Anesthetized Dogs

Journal of Veterinary Medical Science

Nobuo SASAKI¹  Ryohei NISHIMURA¹  Hirokazu TSUBONE²  Tatsushi MUTOH¹ 

[1] Laboratories of Veterinary Surgery, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo;Laboratories of Comparative Pathophysiology, Division of Veterinary Medical Science, Graduate School of Agricultural and Life Sciences, The University of Tokyo

关键词: autonomic nervous blockade;    canine;    cardiovascular reflex;    capsaicin;    distilled water;   

DOI  :  10.1292/jvms.59.801

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(30)Cited-By(11)Cardiovascular reflex mechanisms by topical laryngeal instillation of capsaicin (CAPS) or distilled water were evaluated in anesthetized chronic tracheostomized dogs. Both CAPS (10 μg/ml) and water instillation into the isolated upper airway caused a significant decrease in heart rate (P<0.05) and a significant increase in blood pressure (P<0.05) from the values before instillation under both spontaneous and controlled ventilation. The bradycardia was significantly reduced by atropine pretreatment (P<0.05) and the hypertension was significantly decreased by phentolamine and propranolol pretreatments (P<0.01). A higher concentration of CAPS (100 μg/m l) instillation considerably reduced the response to subsequent CAPS (100 μg/ml) instillation, whereas the response to water was sustained, indicating the desensitization of laryngeal CAPS-sensitive endings. All the reflex responses to CAPS and water were eliminated by topical anesthesia with lidocaine. It was concluded that the laryngeal cardiovascular reflex responses were mediated by the afferents such as the laryngeal CAPS-sensitive presumably C-fiber endings or water-responsive receptors and by both the parasympathetic and sympathetic nervous systems as efferents.

【 授权许可】

Unknown