Effects of Pioglitazone on Stearoyl-CoA Desaturase in Obese Zucker fa/fa Rats

Journal of Pharmacological Sciences

Naomi Kudo¹  Atsushi Mitsumoto²  Tomoaki Toyama¹  Yoichi Kawashima¹  Masazumi Nishikawa³  Yasuhide Hibino¹ 

[1] Faculty of Pharmaceutical Sciences, Josai University, Japan;Faculty of Pharmaceutical Sciences, Josai International University, Japan;School of Food, Agricultural and Environmental Sciences, Miyagi University, Japan

关键词: pioglitazone;    stearoyl-CoA desaturase;    palmitoyl-CoA elongase;    oleic acid;   

DOI  :  10.1254/jphs.FP0060997

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(32)Cited-By(9)The effects of a peroxisome proliferator activated receptor γ (PPARγ) agonist on hepatic stearoyl-CoA desaturase (SCD) in insulin-resistant and obese Zucker fa/fa rats were studied. The administration of pioglitazone, a PPARγ agonist, to Zucker obese rats greatly improved their insulin sensitivity. The treatment of Zucker obese rats with pioglitazone did not affect the index of fatty acid desaturation of either serum or liver. Hepatic SCD activity and the mRNA level of SCD1 were not changed by treatment of the rats with pioglitazone. The activity of palmitoly-CoA chain elongase, which is involved in the biosynthesis of oleic acid in concert with SCD, was not significantly altered when Zucker obese rats received pioglitazone. Although neither the activity nor mRNA expression of acyl-CoA oxidase was changed by treatment of Zucker obese rats with pioglitazone, the mRNA expressions of both sterol regulatory element-binding protein-1c and acetyl-CoA carboxylase sensitively responded to the challenge by pioglitazone. These results suggest that the insulin sensitivity of insulin-resistant and obese Zucker fa/fa rats is improved by pioglitazone independently of SCD activity.

【 授权许可】

Unknown