The Binding of Curcumin to Various Types of Canine Amyloid Proteins

Journal of Veterinary Medical Science

Mayu MUTSUGA¹  James K. CHAMBERS¹  Kazuyuki UCHIDA¹  Meina TEI¹  Hiroyuki NAKAYAMA¹ 

[1] Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113-8657, Japan

关键词: amyloid;    animals;    Congo red;    curcumin;   

DOI  :  10.1292/jvms.11-0420

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(17)Cited-By(1)Curcumin is a constituent phenol compound of turmeric, and has been used as a dietary spice and Indian medicine. Curcumin has been reported to inhibit the formation of amyloid β fibrils and aggregation. In this study, the binding activity of curcumin to various types of canine amyloid was examined. Tissue samples used were lesions of AA, AL, amyloid of canine amyloid-producing odontogenic tumor (Aapot), and senile cardiovascular amyloid (ScA). Curcumin stained all types of amyloid. The binding of curcumin to AA, ScA, and AL was lost by the KMnO4 treatment, but Aapot maintained the binding. These findings indicate that curcumin binds several types of amyloid, while the binding sites of amyloid molecules might be different from that of Congo red.

【 授权许可】

Unknown