Clinical impact of women with gestational diabetes mellitus by the new consensus criteria: two year experience in a single institution in Japan

Endocrine Journal

Marie Fukutake¹  Yasunori Yoshimura¹  Yoko Izumi¹  Yoshifumi Saisho²  Kensuke Sakai¹  Satoru Ikenoue¹  Tadashi Matsumoto¹  Yoshifumi Kasuga¹  Kazuhiro Minegishi¹  Kei Miyakoshi¹ 

[1] Department of Obstetrics and Gynecology, Keio University School of Medicine, Tokyo 160-8582, Japan;Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan

关键词: The new consensus criteria;    Gestational diabetes mellitus;    Large-for gestational age;    Gestational hypertension;   

DOI  :  10.1507/endocrj.EJ13-0496

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(16)Cited-By(4)There is a paucity of information on perinatal data regarding gestational diabetes mellitus (GDM) by the new criteria from a real experience because the number of health care associations implementing the new criteria is still limited.The aim of this study is to investigate perinatal features of the new criteria-defined GDM.We reviewed a total of 995 women with singleton pregnancy that underwent GDM screening followed by a diagnostic oral glucose tolerance test (OGTT).All women found to have GDM underwent self-monitoring of blood glucose measurements as well as dietary management.Insulin treatment was initiated when dietary treatment did not achieve the glycemic goal.Of the 995 women, 141 had GDM (14.2%): 104 with one, 27 with two, and 10 with three abnormal OGTT values.Women with two or three abnormal OGTT values (2/3-AV) needed insulin treatment more frequently than those with one abnormal OGTT value (1-AV) (70.3% vs 23.1%, P < 0.0001).After adjustment for age, pregravid overweight, gestational weeks at diagnosis, a first-degree family history of diabetes was correlated with the implementation of insulin treatment in women with 1-AV (adjusted odds ratio 3.9; 95% Confidence Interval 1.7-9.2; P = 0.001).When compared perinatal outcomes between women with normal glucose tolerance and GDM, fetal growth and the occurrence of pregnancy-induced hypertension were comparable between the two groups.Our data suggest that the IADPSG-defined GDM with 1-AV show less severe glucose intolerance, but might be at risk of insulin requirement when a first-degree family history of diabetes exists.

【 授权许可】

Unknown