Journal of Pharmacological Sciences | |
Involvement of GABAA Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice | |
Katsunori Iwasaki2  Michihiro Fujiwara2  Nobuaki Egashira2  Megumi Osajima2  Kenichi Mishima2  Ryozo Oishi1  Kazuhide Hayakawa2  | |
[1] Department of Pharmacy, Kyushu University Hospital, Japan;Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan | |
关键词: theanine; focal cerebral ischemia; γ-aminobutyric acidA (GABAA) receptor; | |
DOI : 10.1254/jphs.SCZ070901 | |
学科分类:药学 | |
来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society | |
【 摘 要 】
References(11)Cited-By(22)We investigated the involvement of γ-aminobutyric acidA (GABAA) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201911300308283ZK.pdf | 444KB | download |