Involvement of GABAA Receptors in the Neuroprotective Effect of Theanine on Focal Cerebral Ischemia in Mice

Journal of Pharmacological Sciences

Katsunori Iwasaki²  Michihiro Fujiwara²  Nobuaki Egashira²  Megumi Osajima²  Kenichi Mishima²  Ryozo Oishi¹  Kazuhide Hayakawa² 

[1] Department of Pharmacy, Kyushu University Hospital, Japan;Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Japan

关键词: theanine;    focal cerebral ischemia;    γ-aminobutyric acidA (GABAA) receptor;   

DOI  :  10.1254/jphs.SCZ070901

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(11)Cited-By(22)We investigated the involvement of γ-aminobutyric acidA (GABAA) receptors in the neuroprotective effect of γ-glutamylethylamide (theanine), a component of Japanese green tea, following a 4-h middle cerebral artery (MCA) occlusion in mice. Theanine (1 mg/kg) reduced the size of the cerebral infarct and alterations of NeuN, GFAP, and Iba 1 expression levels at 24 h after MCA occlusion. This neuroprotective effect of theanine was prevented by bicuculline (GABAA-receptor antagonist, 10 mg/kg) but not 3-mercaptopropionic acid (glutamate decarboxylase inhibitor). These results suggest that the neuroprotective effect of theanine is mediated, at least in part, by GABAA receptors.

【 授权许可】

Unknown