Low circulating ghrelin levels in women with polycystic ovary syndrome: a systematic review and meta-analysis

Endocrine Journal

Tian Gao³  Guifang Cao³  Fuhou Chang¹  Lang Wu² 

[1] Center for safty evaluation of drugs, Inner Mongolia Medical University, Hohhot, MO, 010110, People’s Republic of China;Center for Clinical and Translational Science, Mayo Clinic, Rochester, Minnesota, 55905, USA;Department of Veterinary, Inner Mongolia Agricultural University, Hohhot, MO, 010018, People’s Republic of China

关键词: Ghrelin level;    Polycystic ovary syndrome;    Meta-analysis;   

DOI  :  10.1507/endocrj.EJ15-0318

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(44)Although numerous, human subject studies evaluating the relationship between circulating ghrelin levels and polycystic ovary syndrome (PCOS) risk have yielded inconsistent findings.We aimed to quantitatively assess the association by summarizing all available evidence from human subject studies.The PubMed and Web of Science databases were searched up to February 2015 for eligible studies.Studies were eligible if they reported circulating ghrelin levels in women with PCOS and healthy women controls.A fixed or random-effects model was used to pool risk estimations.Twenty studies including 894 PCOS patients and 574 controls were included in the meta-analysis.The studies had fair methodological quality.The pooling analysis of all available studies revealed that ghrelin levels were significantly lower in PCOS patients than in controls, with standardized mean difference of -0.40 (95% CI: -0.73, -0.08).The significant association persisted in many subgroup strata.However, the heterogeneity across studies was considerable and not eliminated in subgroup analyses.Meta-regression analysis further suggested that the heterogeneity might be relevant to variability in study location, PCOS relevant factors like HOMA-IR ratio, as well as other factors not assessed.In conclusion, our meta-analysis suggested that ghrelin levels were significantly lower in PCOS patients than in controls.Further studies with large sample sizes are warranted to replicate our findings.

【 授权许可】

Unknown