Impact of the CSM advice on thioridazine on general practitioner prescribing behaviour in Leeds: time series analysis

British Journal of General Practice

Alison J Roberts¹  Nat M J Wright¹  Gillian Laurence¹  Charlotte N E Tompkins¹  Victoria L Allgar¹  Darren C Greenwood¹ 

[1] Centre for Research in Primary Care, Leeds

关键词: general practitioner prescribing;    long QT syndrome;    prescribing advice;    primary health care;    psychotropic drugs;    telefacsimile;   

DOI  :  

学科分类：卫生学

来源: Royal College of General Practitioners

【 摘 要 】

In December 2000, the Committee for Safety of Medicines (CSM) advised that thioridazine may prolong QT intervals risking arrhythmias. We investigated the impact on general practitioner prescribing of thioridazine using a time series analysis. Numbers of items and costs of antipsychotics and benzodiazepines prescribed in Leeds from May 1999 until April 2002 were collated. Post-advice, thioridazine prescriptions dropped by 810 items per month (95% confidence interval = 420 to 1200, P<0.001) but others increased slightly in response. Costs mimicked these changes. Fresh criteria are proposed for appraising the quality of evidence needed to inform future urgent facsimile transmissions.

【 授权许可】

Unknown