Mechanisms of TRH-induced GH Release (Paradoxical Response) in Human Somatotroph Adenoma Cells

Endocrine Journal

Shuhei HAYASHI¹  Hiroko OKINAGA¹  Junko YASUFUKU-TAKANO¹  Toshiro FUJITA¹  Koji TAKANO¹  Akira TERAMOTO² 

[1] Department of Nephrology and Endocrinology, University of Tokyo Faculty of Medicine;Department of Neurosurgery, Nippon Medical School

关键词: Paradoxical response;    TRH;    Somatotroph adenoma cell;    PKC;    GH secretion;   

DOI  :  10.1507/endocrj.52.763

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(14)Cited-By(3)The mechanisms of paradoxical TRH response in human somatotroph adenoma cells were investigated using intracellular calcium measurement and static incubation assay. Intracellular calcium measurement revealed that TRH induces a biphasic response: a transient increase followed by a sustained plateau. The transient phase was due to the calcium release from IP3-regulated intracellular calcium store and the subsequent sustained phase was due to the calcium influx through the voltage-gated calcium channels. The signal transduction mechanism of the calcium plateau involved protein kinase C. These calcium responses, especially the second phase, was responsible for the TRH-induced GH release.

【 授权许可】

Unknown