Journal of Veterinary Medical Science | |
Effects of Griseoviridin and Viridogrisein against Swine Dysentery in Experimental Infection by Using Mice and Pigs | |
Toshihiko ASANO2  Yoshikazu ADACHI1  | |
[1] Animal Health Laboratory, School of Agriculture, Ibaraki University;Research Center, Astellas Pharma Inc. | |
关键词: Brachyspira hyodysenteriae; griseoviridin; swine dysentery; viridogrisein; | |
DOI : 10.1292/jvms.68.555 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(16)Cited-By(2)Griseoviridin, a known antibiotic produced by Streptomyces cacaoi subsp. cacaoi, was found to be active against Brachyspira hyodysenteriae-the bacterium causing swine dysentery. An in vitro synergism is observed when it is used in combination with viridogrisein-a simultaneously produced antibiotic. In mouse experiments, the effect of griseoviridin alone was less than that of lincomycin-a commercially available swine dysentery medication. However, a 1:1 mixture of griseoviridin and viridogrisein revealed a noticeable synergistic effect. In an evaluation using pigs artificially infected with B. hyodysenteriae, a large difference was not observed between the effect of griseoviridin alone and that in combination with viridogrisein. Nevertheless, griseoviridin alone exhibited a therapeutic effect superior to that of lincomycin.
【 授权许可】
Unknown
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RO201911300303678ZK.pdf | 159KB | download |