Effects of Griseoviridin and Viridogrisein against Swine Dysentery in Experimental Infection by Using Mice and Pigs

Journal of Veterinary Medical Science

Toshihiko ASANO²  Yoshikazu ADACHI¹ 

[1] Animal Health Laboratory, School of Agriculture, Ibaraki University;Research Center, Astellas Pharma Inc.

关键词: Brachyspira hyodysenteriae;    griseoviridin;    swine dysentery;    viridogrisein;   

DOI  :  10.1292/jvms.68.555

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(16)Cited-By(2)Griseoviridin, a known antibiotic produced by Streptomyces cacaoi subsp. cacaoi, was found to be active against Brachyspira hyodysenteriae-the bacterium causing swine dysentery. An in vitro synergism is observed when it is used in combination with viridogrisein-a simultaneously produced antibiotic. In mouse experiments, the effect of griseoviridin alone was less than that of lincomycin-a commercially available swine dysentery medication. However, a 1:1 mixture of griseoviridin and viridogrisein revealed a noticeable synergistic effect. In an evaluation using pigs artificially infected with B. hyodysenteriae, a large difference was not observed between the effect of griseoviridin alone and that in combination with viridogrisein. Nevertheless, griseoviridin alone exhibited a therapeutic effect superior to that of lincomycin.

【 授权许可】

Unknown