Pneumonitis caused by cytomegalovirus in dead aids patients

Revista Cubana de Hematología, Inmunología y Hemoterapia

Capó de la Paz, Virginia²  Arencibia Núñez, Alberto¹  Ponce Vitar, Jorge²  Valdés Cabrera, Francisco¹  Fonseca Gómez, Carlos²  Machín García, Sergio¹  Serrano Mirabal, Jesús¹  Forrellat Barrios, Mariela¹ 

[1] Instituto de Hematología e Inmunología, La Habana, Cuba;Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba

关键词: neumonitis;    cytomegalovirus;    HIV;    AIDS     INTRODUCCIÓN La infección por citomegalovirus (CMV) puede ser congénita o adquirida;    y se ha reconocido como un virus que infecta al ser humano El CMV es considerado un germen oportunista común entre individuos con infección por el virus de inmunodeficiencia humana(VIH) y con frecuencia produce enfermedades en diferentes órganos1;   

DOI  :  

学科分类：生理学与病理学

来源: SciELO

【 摘 要 】

Introduction : Cytomegalovirus (CMV) is considered a common opportunistic germ in individuals infected with human immunodeficiency virus (HIV) often causing disease in different organs. Objective: To determine the incidence of this condition in our environment. Material and Methods: A descriptive, ambispective study that included 105 of the 674 autopsies of AIDS patients died at the Institute of Tropical Medicine "Pedro Kouri, with postmortem diagnosis of CMV disease, between 1986 and 2008. Sociodemographic variables, main organs affected, clinical and pathological correlation, clinical and laboratory findings, relation between CD4 + T cells count and clinical forms of the disease are described. Results: Males predominated in a ratio 4:1 as well as white skin color (80.2%). 66.6% of patients had disseminated disease. Adrenal glands (41.9%), gastrointestinal tract (30.5%) and brain (17.1%) were the most affected organs. Fever (51.4%), diarrhea (42.9%), seizures (31.4%) and physical consumption (17.1%) were the most frequent symptoms. LDH levels >600 mmol/L were strongly associated to CMV as cause of death (p = 0.005). Nearly 70 % of patients had less than 100 cells/µL and 37.5 % less than 50 cells/µL, although this had no significant influence in the clinical forms of presentation (p = 0.641). Conclusions: CMV disease was mainly diagnosed postmortem, usually spread and in association with high levels of LDH and CD4 count lesser than 100 cells/µL.

【 授权许可】

Unknown