Developmental Changes in Hepatic Antioxidant Capacity Are Age-and Sex-Dependent

Journal of Pharmacological Sciences

Abby C. Collier¹  Isaac W. Brown¹  Jessica M-L. Chock¹  Shogo J. Miyagi¹ 

[1] Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii, USA

关键词: oxidative stress;    pediatric liver disease;    detoxification enzyme;   

DOI  :  10.1254/jphs.09223SC

学科分类：药学

来源: Nihon Yakuri Gakkai Henshuubu / Japanese Pharmacological Society

【 摘 要 】

References(15)Cited-By(8)Developmental inadequacy in hepatic antioxidant defenses may contribute to chemical toxicity and pediatric liver diseases. We measured a comprehensive panel of antioxidants in liver tissue from 27 normal pediatric donors. Glutathione reductase declined with age (P = 0.008, r = −0.54, Spearman) while microsomal glutathione-S-transferase increased (GST, P<0.001, r = 0.81). Males had significantly lower superoxide dismutase and vitamin E (P<0.05) and may have lower glutathione reductase (P = 0.06), while females show less cytosolic GST (P = 0.07). Hepatic antioxidants are high in neonates, decline throughout childhood, and then increase in adolescence to adult levels.

【 授权许可】

Unknown