Persistence of High Virus Neutralizing Antibody Titers in Cats Experimentally Infected with Feline Immunodeficiency Virus

Journal of Veterinary Medical Science

Takeshi MIKAMI¹  Masayuki SHIMOJIMA¹  Mariko KOHMOTO¹  Yasushi KAWAGUCHI¹  Yukako SHIMOJIMA¹  Gouki INADA¹  Takayuki MIYAZAWA¹  Marcelo Ricardo PECORARO¹  Keizo TOMONAGA¹  Yasuo INOSHIMA¹  Yasuhiro IKEDA¹ 

关键词: antibody;    FIV;    neutralization test;   

DOI  :  10.1292/jvms.58.925

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(28)Cited-By(4)The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.

【 授权许可】

Unknown