Sedative effects of intramuscular alfaxalone administered to cats

Journal of Veterinary Medical Science

Kirby PASLOSKE²  Tadashi SANO³  Sho FUKUI¹  Tomohito ISHIZUKA¹  Kenjiro MIYOSHI¹  Kodai KAWASE¹  Jun TAMURA¹  Norihiko OYAMA¹  Takaharu ITAMI¹  Kazuto YAMASHITA¹ 

[1] Department of Small Animal Clinical Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069�?8501, Japan;Jurox Pty Ltd., Rutherford, NSW 2320, Australia;Department of Veterinary Nursing Sciences, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069�?8501, Japan

关键词: alfaxalone;    feline;    intramuscular administration;    sedation;   

DOI  :  10.1292/jvms.14-0200

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(33)The sedative effects of intramuscular (IM) alfaxalone in 2-hydroxypropyl-beta-cyclodextrin (alfaxalone-HPCD) were evaluated in cats. The cats were treated with alfaxalone-HPCD in five occasions with a minimum 14-day interval between treatments: an IM injection of 1.0 mg/kg (IM1), 2.5 mg/kg (IM2.5), 5 mg/kg (IM5) or 10 mg/kg (IM10), or an intravenous injection of 5 mg/kg (IV5). The sedative effects were evaluated subjectively using a composite measurement scoring system (a maximum score of 16). Cardio-respiratory variables were measured non-invasively. The median sedation scores peaked at 10 min (score 9), 15 min (score 14), 10 min (score 16), 10 to 20 min (score 16) and 2 to 5 min (score 16) after the IM1, IM2.5, IM5, IM10 and IV5 treatments, respectively. The IM5 treatment produced longer lasting sedation, compared to the IV5 treatment. Durations of maintenance of lateral recumbency after the IM10 treatment (115 ± 22 min) were longer than those after the IM2.5 (40 ± 15 min), IM5 (76 ± 21 min) and IV5 treatments (50 ± 5 min). Cardio-respiratory variables remained within clinically acceptable ranges, except for each one cat that showed hypotension (<60 mmHg) after the IM10 and IV5 treatments. Tremors, ataxia and opisthotonus-like posture were observed during the early recovery period after the IM2.5, IM5, IM10 and IV5 treatments. In conclusion, IM alfaxalone-HPCD produced dose-dependent and clinically relevant sedative effect at 2.5 to 10 mg/kg in healthy cats. Hypotension may occur at higher IM doses of alfaxalone-HPCD.

【 授权许可】

Unknown