Journal of Veterinary Medical Science | |
Antimicrobial susceptibility and molecular characterization of macrolide resistance of Mycoplasma bovis isolates from multiple provinces in China | |
Hong-Xia MA1  Bo-Yan JIA1  Zhi-Hua PEI1  Jiu-Qing XIN2  Ling-Cong KONG1  Shu-Ming LIU1  Duo GAO1  Yun-Hang GAO1  Zi WANG1  | |
[1] College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street No.#2888, Changchun 130118, P.R. China;National Contagious Bovine Pleuropneumonia Reference Laboratory, Division of Bacterial Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin 150000, P.R. China | |
关键词: antimicrobial susceptibility; bovine respiratory infection; macrolides; mycoplasma bovis; target mutation; | |
DOI : 10.1292/jvms.15-0304 | |
学科分类:兽医学 | |
来源: Japanese Society of Veterinary Science | |
【 摘 要 】
References(18)Cited-By(2)Mycoplasma bovis has spread widely throughout the world via animal movement and has become an important pathogen of bovine respiratory disease. However, the minimum inhibitory concentrations of antimicrobials for Mycoplasma bovis have not been studied in China. The objective of this study was to determine the prevalence and antibiotic resistance of Mycoplasma bovis isolated from young cattle with respiratory infection in China. Mycoplasma bovis was detected in 32/45 bovine respiratory infection outbreaks at beef farms in 8 provinces in China. The isolates were susceptible or had medium sensitivity to ciprofloxacin, enrofloxacin and doxycycline, but were frequently resistant to macrolides (13/32, 41%). An A2058G (Escherichia coli Numbering) mutation located in the rrnA operon in domain V of 23S rRNA was observed in strains that were resistant to macrolides. This single mutations at the rrnA operon in domain V of 23S rRNA may play an important role in the resistance of Mycoplasma bovis strains to macrolides.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201911300291543ZK.pdf | 459KB | download |