Antimicrobial susceptibility and molecular characterization of macrolide resistance of Mycoplasma bovis isolates from multiple provinces in China

Journal of Veterinary Medical Science

Hong-Xia MA¹  Bo-Yan JIA¹  Zhi-Hua PEI¹  Jiu-Qing XIN²  Ling-Cong KONG¹  Shu-Ming LIU¹  Duo GAO¹  Yun-Hang GAO¹  Zi WANG¹ 

[1] College of Animal Science and Technology, Jilin Agricultural University, Xincheng Street No.#2888, Changchun 130118, P.R. China;National Contagious Bovine Pleuropneumonia Reference Laboratory, Division of Bacterial Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, Harbin 150000, P.R. China

关键词: antimicrobial susceptibility;    bovine respiratory infection;    macrolides;    mycoplasma bovis;    target mutation;   

DOI  :  10.1292/jvms.15-0304

学科分类：兽医学

来源: Japanese Society of Veterinary Science

【 摘 要 】

References(18)Cited-By(2)Mycoplasma bovis has spread widely throughout the world via animal movement and has become an important pathogen of bovine respiratory disease. However, the minimum inhibitory concentrations of antimicrobials for Mycoplasma bovis have not been studied in China. The objective of this study was to determine the prevalence and antibiotic resistance of Mycoplasma bovis isolated from young cattle with respiratory infection in China. Mycoplasma bovis was detected in 32/45 bovine respiratory infection outbreaks at beef farms in 8 provinces in China. The isolates were susceptible or had medium sensitivity to ciprofloxacin, enrofloxacin and doxycycline, but were frequently resistant to macrolides (13/32, 41%). An A2058G (Escherichia coli Numbering) mutation located in the rrnA operon in domain V of 23S rRNA was observed in strains that were resistant to macrolides. This single mutations at the rrnA operon in domain V of 23S rRNA may play an important role in the resistance of Mycoplasma bovis strains to macrolides.

【 授权许可】

Unknown